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Pharmacology & Mechanisms

67 threads · 891 posts
N
Study GLP-1R desensitization — β-arrestin-mediated internalization
NeuroNate · Yesterday at 6:41 PM
18Replies
396Views
N
NeuroNate
Yesterday at 6:41 PM
P
Study Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance
PeptideChemSF · Yesterday at 4:59 PM
13Replies
263Views
P
PeptideChemSF
Yesterday at 4:59 PM
P
Study Semaglutide albumin binding and the C-18 fatty acid linker
PeptideChemSF · Yesterday at 12:17 PM
17Replies
305Views
P
PeptideChemSF
Yesterday at 12:17 PM
N
Study GIP receptor pharmacology — why GIP agonism enhances GLP-1
NeuroNate · Yesterday at 4:36 AM
13Replies
219Views
N
NeuroNate
Yesterday at 4:36 AM
D
Study Glucagon receptor signaling — hepatic glycogenolysis and lipolysis
Dr.MetabolicMD · Thursday at 5:56 PM
16Replies
226Views
D
Dr.MetabolicMD
Thursday at 5:56 PM
P
Study Structure-activity relationships of GLP-1 analogs
PeptideChemSF · Thursday at 4:17 AM
12Replies
407Views
P
PeptideChemSF
Thursday at 4:17 AM
N
Guide GLP-1R expression map — central and peripheral tissue distribution
NeuroNate · Wednesday at 11:38 AM
2Replies
148Views
N
NeuroNate
Wednesday at 11:38 AM
SP
Study Tachyphylaxis vs tolerance — pharmacological distinction on GLP-1
SarahChen_PharmD · Tuesday at 4:01 PM
19Replies
515Views
SP
SarahChen_PharmD
Tuesday at 4:01 PM

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N
Study cAMP signaling cascade from GLP-1R activation — complete pathway map
NeuroNate · Monday at 5:24 PM
14Replies
385Views
N
NeuroNate
Monday at 5:24 PM
P
Study Semaglutide fatty acid sidechain — acylation and albumin binding kinetics
PeptideChemSF · Sunday at 3:48 PM
19Replies
435Views
P
PeptideChemSF
Sunday at 3:48 PM
N
Study GLP-1/GIP receptor co-agonism — synergy vs additive effects
NeuroNate · Mar 7, 2026
14Replies
334Views
N
NeuroNate
Mar 7, 2026
P
Study Peptide degradation pathways — DPP-4 and NEP 24.11 cleavage sites
PeptideChemSF · Mar 6, 2026
18Replies
345Views
P
PeptideChemSF
Mar 6, 2026
JP
Study Receptor internalization and recycling — β-arrestin vs clathrin pathways
josh_phd_bmore · Mar 4, 2026
13Replies
538Views
JP
josh_phd_bmore
Mar 4, 2026
RC
Study Molecular dynamics simulations of GLP-1R binding — computational data
raj_cambridge · Mar 3, 2026
18Replies
630Views
RC
raj_cambridge
Mar 3, 2026
P
Study GLP-1R allosteric modulators — future of non-peptide agonists
PeptideChemSF · Mar 1, 2026
12Replies
473Views
P
PeptideChemSF
Mar 1, 2026
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