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Pharmacology & Mechanisms

67 threads · 891 posts
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Guide Incretin effect in healthy vs T2DM — why GLP-1 response is blunted in diabetes
Dr.MetabolicMD · Feb 27, 2026
13Replies
471Views
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Dr.MetabolicMD
Feb 27, 2026
D
Study Enteroendocrine L-cell biology — endogenous GLP-1 secretion and regulation
Dr.GutHealth · Feb 25, 2026
20Replies
546Views
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Dr.GutHealth
Feb 25, 2026
P
Study Structure-function of tirzepatide — unimolecular dual agonist design
PeptideChemSF · Feb 23, 2026
14Replies
437Views
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PeptideChemSF
Feb 23, 2026
NN
New Can someone explain how this drug works like I am not a scientist
nick_newbie · Feb 22, 2026
9Replies
372Views
NN
nick_newbie
Feb 22, 2026
J
New Why does it stop working after a while for some people
JenPlateau · Feb 20, 2026
6Replies
466Views
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JenPlateau
Feb 20, 2026
TF
Hot So the drug literally changes your brain?? That is wild
tammy_FL · Feb 17, 2026
26Replies
905Views
TF
tammy_FL
Feb 17, 2026
JS
New Is there a simple version of how sema vs tirz are different
jason_sac26 · Feb 15, 2026
4Replies
426Views
JS
jason_sac26
Feb 15, 2026
S
New My pharmacist tried to explain the mechanism and my eyes glazed over
SaraMom3 · Feb 12, 2026
6Replies
462Views
S
SaraMom3
Feb 12, 2026

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TS
New GLP-1R desensitization — what worked for you?
traveltech_sara · Feb 9, 2026
11Replies
526Views
TS
traveltech_sara
Feb 9, 2026
NP
New Biased agonism at GLP-1R — my results so far
nancy_portland · Feb 6, 2026
12Replies
520Views
NP
nancy_portland
Feb 6, 2026
CA
Hot Semaglutide albumin binding and the C-18 fatty acid linker — anyone have experience?
cory_ATX · Feb 3, 2026
27Replies
1.1KViews
CA
cory_ATX
Feb 3, 2026
CT
Study Has anyone dealt with gip receptor pharmacology?
CarlaRPh_TPA · Jan 31, 2026
14Replies
769Views
CT
CarlaRPh_TPA
Jan 31, 2026
GN
Guide Glucagon receptor signaling — looking for input
gary_naperville · Jan 28, 2026
8Replies
618Views
GN
gary_naperville
Jan 28, 2026
TW
New Structure-activity relationships of GLP-1 analogs — need advice
tane_welly · Jan 24, 2026
5Replies
556Views
TW
tane_welly
Jan 24, 2026
DC
Hot GLP-1R expression map — 12 month update
DanielChem_CHI · Jan 21, 2026
28Replies
903Views
DC
DanielChem_CHI
Jan 21, 2026
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