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ForumsNutrition & SupplementationCreatine monohydrate + GLP-1 — need advice Page 2

Creatine monohydrate + GLP-1 — need advice

rachel_ABQ Thu, Aug 7, 2025 at 11:03 AM 11 replies 1,408 viewsPage 2 of 3
CanadaChris
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890
Nov 2024
Toronto, CA
Aug 7, 2025 at 1:53 PM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

13 9Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 10 others
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hyun_seoul
Member
345
1,456
Jul 2024
Seoul, KR
Aug 7, 2025 at 2:10 PM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

10 5GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 7 others
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JakeBK_lifts
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523
2,345
Jul 2024
Brooklyn, NY
Aug 7, 2025 at 2:27 PM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

5 18LabKate, kate.chem, DataDave and 2 others
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A1cHero_PHX
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523
2,678
Jul 2024
Phoenix, AZ
Aug 7, 2025 at 2:44 PM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

28 3chris_chi24, tampaLisa73, KarenAZ_mom and 25 others
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