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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsHas anyone dealt with why does it stop working after a while for some people? Page 2

Has anyone dealt with why does it stop working after a while for some people?

PeptideChemSF Mon, Nov 24, 2025 at 12:51 AM 27 replies 1,132 viewsPage 2 of 6
NeuroNate
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Nov 24, 2025 at 3:41 AM#6

Can confirm — same results here.

47 19jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 44 others
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PeptideChemSF
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Nov 24, 2025 at 3:58 AM#7

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with why.

To answer TirzTom: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Nov 24, 2025 at 7:58 AM
8 13dave_SLC, FDA_TrackerJim, ricardo_MIA and 5 others
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anders_CPH
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Feb 2024
Copenhagen, DK
Nov 24, 2025 at 4:15 AM#8

Adding my data to this Has anyone dealt with why discussion:

MetricBaselineMonth 5Month 8
Weight246 lbs246 lbs221 lbs
A1C7.0%6.0%5.4%
hsCRP5.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

Last edited: Nov 24, 2025 at 8:15 AM
34 15AussieAnna, BethLabQueen, ChrisMacros and 31 others
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nick_newbie
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Nov 24, 2025 at 4:32 AM#9

+1 to PeptideChemSF. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Has anyone dealt with why.

17 20LarryQC_SD, wanda_boise, NurseAsh_DET and 14 others
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PharmHunterJen
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Jul 2024
Illinois
Nov 24, 2025 at 4:49 AM#10

Slightly tangential to Has anyone dealt with why but NurseKim_ATL reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

45 3mike_mealprep, NicoleRaleigh, james_edin and 42 others
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