Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.
Tagging this for the weekly digest. 👍
Clinical perspective on Why does it stop working after a while:
I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.
Admin said:Consult your healthcare provider
I respect Admin perspective but I think this oversimplifies things a bit. Re: Why does it stop working after — the subgroup analyses show meaningful heterogeneity.
I am not saying Admin wrong entirely — just that the picture is more nuanced than a blanket statement. The STEP data specifically shows dose-dependent variation.
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