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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — anyone have experience? Page 5

Why does it stop working after a while for some people — anyone have experience?

kim_atl_prep Mon, Jun 23, 2025 at 5:27 PM 38 replies 2,109 viewsPage 5 of 8
traveltech_sara
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Jan 2025
Remote, USA
Jun 24, 2025 at 12:32 AM#21

Subscribing to this thread. Why does it stop working is exactly what I've been researching. 🙏

Last edited: Jun 24, 2025 at 3:32 AM
42 0MeganSA_TX, LarryQC_SD, wanda_boise and 39 others
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amy_econ_NJ
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May 2024
Princeton, NJ
Jun 24, 2025 at 12:49 AM#22

Slightly tangential to Why does it stop working but bri_stats reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

37 24hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 34 others
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SandraNC_45
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Sep 2024
Charlotte, NC
Jun 24, 2025 at 1:06 AM#23

Bookmarked 📌 The Why does it stop info in this thread is essential. Coming back to this for sure.

Last edited: Jun 24, 2025 at 6:06 AM
4 19NicoleRaleigh, james_edin, FranDenver and 1 other
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COA_Karl
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Jan 2024
Pennsylvania
Jun 24, 2025 at 1:23 AM#24

Reading this thread on Why does it stop working hits close to home. Dad of 2 checking in — I started at 273 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 48 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Why does it stop — take the leap. It was the best health decision I have ever made. ❤️

25 11tommy_boulder, hyun_seoul, jim_asheville and 22 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Jun 24, 2025 at 1:40 AM#25

Adding my data to this Why does it stop working discussion:

MetricBaselineMonth 3Month 6
Weight244 lbs239 lbs219 lbs
A1C6.8%5.8%5.2%
hsCRP8.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

39 18Dr.MetabolicMD, RetaRick_CA, JenPlateau and 36 others
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