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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHas anyone dealt with tirzepatide cardiovascular safety? Page 8

Has anyone dealt with tirzepatide cardiovascular safety?

carlos_SATX Thu, Sep 18, 2025 at 10:20 PM 41 replies 1,657 viewsPage 8 of 9
PharmHunterJen
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Jul 2024
Illinois
Sep 19, 2025 at 9:40 AM#36

Slightly tangential to Has anyone dealt with but BenResearch_OR reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Sep 19, 2025 at 3:40 PM
6 22Dr.LipidDallas, alex_tucson, kevin_tulsa and 3 others
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PharmD_Rodriguez
Senior Member
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Jan 2024
Miami, FL
Sep 19, 2025 at 9:57 AM#37

Bookmarked 📌 The Has anyone dealt info in this thread is essential. Coming back to this for sure.

14 2TinaHashiRN, robert_kc, dan_philly and 11 others
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MikeKY_noInsulin
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Oct 2024
Louisville, KY
Sep 19, 2025 at 10:14 AM#38

Reading this thread on Has anyone dealt with hits close to home. Night shift nurse — I started at 295 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 70 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Has anyone dealt — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Sep 19, 2025 at 1:14 PM
3 0Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC
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Dr.NateNeph
VIP Member
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Dec 2023
Houston, TX
Sep 19, 2025 at 10:31 AM#39

Adding my data to this Has anyone dealt with discussion:

MetricBaselineMonth 3Month 8
Weight266 lbs226 lbs201 lbs
A1C7.0%5.8%5.4%
hsCRP5.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

19 23B12Beth, RickReta_CO, PharmHunterJen and 16 others
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steph_laguna
Member
234
1,123
Nov 2024
Laguna Beach, CA
Sep 19, 2025 at 10:48 AM#40

Reading this thread on Has anyone dealt with hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Has anyone dealt — take the leap. It was the best health decision I have ever made. ❤️

44 14marco_milano, pam_columbus, nick_SD_fit and 41 others
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