🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHeart failure hospitalization reduction on semaglutide — looking for input Page 5

Heart failure hospitalization reduction on semaglutide — looking for input

marcus_mpls Sun, Jun 15, 2025 at 6:31 PM 28 replies 1,408 viewsPage 5 of 6
emily_PDX
Member
245
1,123
Nov 2024
Portland, OR
Jun 16, 2025 at 1:36 AM#21

ZaraB_AL — that is really helpful context on Heart failure. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

13 17julia.endo, JessicaM_2024, TomFromTexas and 10 others
Reply Quote Save Share Report
PharmacoVig_BOS
Senior Member
1,567
8,901
Feb 2024
Boston, MA
Jun 16, 2025 at 1:53 AM#22

To answer stefan_berlin's question specifically:

From a clinical standpoint, Heart failure hospitalization is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

49 2Dr.GutHealth, amsterdam_pete, LondonLisa and 46 others
Reply Quote Save Share Report
SteveThurs
Member
523
2,345
Sep 2024
Wisconsin
Online
Jun 16, 2025 at 2:10 AM#23

Thank you emily_PDX! This is incredibly helpful. Taking this to my next appointment. 🙏

20 3SleepFixSam, PurityPaulOR, MaxMetOK and 17 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides
labquiet_amy
Senior Member
1,234
6,789
Mar 2024
Cambridge, MA
Jun 16, 2025 at 2:27 AM#24

Relevant to Heart failure hospitalization — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 207 → 107 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

3 17bri_stats, pete_manc_UK, anna.melb_AU
Reply Quote Save Share Report
wanda_boise
Member
412
1,890
Aug 2024
Boise, ID
Jun 16, 2025 at 2:44 AM#25

Slightly tangential to Heart failure but emily_PDX reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 16, 2025 at 7:44 AM
21 10ben_calgary, patPC_UT, Dr.DermMIA and 18 others
Reply Quote Save Share Report

Similar Threads

SELECT trial: 20% MACE reduction — mechanistic deep dive7 replies
Semaglutide cardiovascular benefit independent of weight loss11 replies
STEP-HFpEF: semaglutide in heart failure with preserved EF15 replies
GLP-1 and arterial inflammation — hsCRP and IL-6 reduction data18 replies
Lp(a) on GLP-1 agonists — any impact on this risk factor?8 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register